The number of calories people burn changes with the time of day, according to a study which could explain why irregularities in eating and sleeping may make people gain weight.Researchers from Brigham and Women’s Hospital and Harvard Medical School in the US found that when at rest, people burn 10 per cent more calories in the late afternoon and early evening than in the early morning hours.The findings, published in the journal Current Biology, reinforce the important role of the circadian clock in governing metabolism.he study could also help explain why irregularities in eating and sleeping schedules due to shift work or other factors may make people more likely to gain weight.“The fact that doing the same thing at one time of day burned so many more calories than doing the same thing at a different time of day surprised us,” said Kirsi-Marja Zitting from the Brigham and Women’s Hospital and Harvard Medical School.To determine changes over the course of the day in metabolism apart from the effects of activity, sleep-wake cycle, and diet, the researchers studied seven people in a special laboratory without any clues about what time it was outside.There were no clocks, windows, phones, or internet.Study participants had assigned times to go to bed and wake up. Each night, those times were adjusted four hours later, the equivalent of travelling westward across four time zones each day for three weeks.“Because they were doing the equivalent of circling the globe every week, their body’s internal clock could not keep up, and so it oscillated at its own pace,” said Jeanne Duffy from Brigham and Women’s Hospital.The study found that eating more protein can delay the risk of disability that can obstruct them in performing basic daily and housekeeping activities independently including self feeding, bathing, dressing and participating in social activities.”Our findings support current thinking about increasing the recommended daily intake of protein to maintain active and healthy ageing,” said Nuno Mendonca, lead researcher from Newcastle University in the UK. “This allowed us to measure metabolic rate at all different biological times of day,” Duffy said.The researchers found that participants’ respiratory quotient, which reflects macronutrient utilisation, varies by circadian phase, too.This measure was lowest in the evening and highest in the biological morning, researchers said.The findings offer the first characterisation of a circadian profile in fasted resting energy expenditure and fasted respiratory quotient, decoupled from effects of activity, sleep-wake cycle, and diet in humans, they said.“It is not only what we eat, but when we eat—and rest—that impacts how much energy we burn or store as fat,” Duffy said.“Regularity of habits such as eating and sleeping is very important to overall health,” he said. For the study, published in the Journal of the American Geriatrics Society, researchers examined 722 participants in North-East England, of whom 60 per cent were women. They provided researchers with information about their daily diet, body weight, height measurements, overall health assessment (including any level of disability), and medical records.
