An effective yet environmentally sustainable method has proved useful in blocking the transmission of mosquito-borne dengue virus, says a recent study.Using a strain of the bacteria Wolbachia, which inhibit mosquitoes from transmitting viruses to humans, researchers at the Universities of Melbourne and Glasgow and the Institute for Medical Research in Malaysia were able to successfully reduce cases of dengue at sites in Kuala Lumpur.Their data published in — Current Biology — shows that mosquitoes carrying the wAlbB strain of Wolbachia, when released into the wild, had the effect of reducing the incidence of dengue cases by 40 per cent.Previously, scientists including Professor Ary Hoffmann from the University of Melbourne, have carried out successful mosquito releases using a different strain of the Wolbachia bacteria, but while this strain was able to invade wild populations in some conditions, it did not appear to be suitable for use in the very hot conditions experienced in equatorial countries such as Malaysia.Now, this international team of researchers from Melbourne, Glasgow and Malaysia has shown that the wAlbB strain of Wolbachia is stable and effective, even in daily peak temperatures of 36° Celsius and higher, as commonly experienced in areas of Malaysia where dengue is prevalent.Prof Hoffmann, from Melbourne University’s Bio21 Institute, said the findings could make a difference to a number of countries who have dengue.”This study provides us with a new Wolbachia strain for field release and highlights disease impact within a complex urban setting where dengue incidence rates are high,” he said.”The intervention succeeded despite ongoing pesticide applications and other challenges that can make it hard for the Wolbachia to become established.
