If you wish to lower your Low-Density LipoproteinCholesterol, called LDL, solid fats like butter and lard are the worst choice, while oils from seeds are the best alternatives, a new study has revealed.The research suggests you should exchange saturated fats with unsaturated fat. Many of the studies establish that mono -and polyunsaturated fats are better for blood lipids than saturated fats swapped out one food source at a time, making it hard to tell which of a plethora of vegetable oils might be most beneficial.Lukas Schwingshackl, a researcher at the German Institute of Human Nutrition, is using sophisticated statistical tools to reduce uncertainty about what the mountain of data in the nutrition literature can tell us. Schwingshackl and colleagues used an emerging technique called network meta-analysis to extract insight from published studies on the effect of various dietary oils on blood lipids. The researchers found that seed oils were the best choice for people looking to improve their cholesterol.Schwingshackl’s team constructed a network meta-analysis showing how different oils and solid fats have in fact been matched up. The researchers rounded up 55 studies dating to the 1980s that assessed the effects of consuming the same amount of calories from two or more different oils on participants’ blood lipids. To be included in the analysis, a study had to compare the effect of two or more oils or fats (from a list of 13) on patients’ LDL, or other blood lipids like total cholesterol, HDL-cholesterol or triglycerides, over at least three weeks.Suppose both butter and sunflower oil had been tested against olive oil. The statistical approaches of network meta-analysis allowed the team to infer a quantitative comparison between butter and sunflower oil, even if they had never faced off in the clinic.Schwingshackl explained, “The beauty of this method is that you can compare a lot of different interventions simultaneously and, in the end, you get a ranking. You can say, ‘this is the best oil for this specific outcome.”In this study, the final ranking indicated that, as your doctor has been telling you for years, solid fats like butter and lard are the worst choice for LDL. The best alternatives are oils from seeds.”Sunflower oil, rapeseed oil, safflower oil and flaxseed oil performed best,” said Schwingshackl.Meta-analyses run the risk of misleading by combining several pieces of low-confidence data into a falsely confident-sounding ranking. In this case, for example, there was not enough evidence to choose a “winner” confidently among the seed oils.What’s more, the oils best at lowering LDL were not the most beneficial for triglycerides and HDL cholesterol. However, with the appropriate caveats in mind, Schwingshackl is optimistic about the potential for network meta-analysis to help researchers synthesize disparate clinical studies in the future.The study appeared in the Journal of Molecular & Cellular Proteomics.
